The aplication of the fractal analysis in oncopathology

by, PhD Lutfi ALIA

Abstract

Fractal analysis is an objective approach that in oncopathology is one of the important fields of application. In this study is present fractal methodologies at histological level that have been successfully applied to characterize pathological features and able to perform differential diagnosis and prognosis in oncopathology. The basic principles and prospects of fractal geometry in pathology are promising. In particular, fractal analysis is emerging as a powerful tool to perform differential diagnosis and prognosis of patients in cancer and other malignancies as well to improve the effectiveness and safety of patient care. All fractal objects have Fractal Dimension FDs, commonly calculated with box counting. Morphometry, the measure of shapes of the structures, can be added to every imaging technique in order to obtain objective indexes. In this field, fractal analysis has been applied to histopathology, cytopathology, and electron microscopy with great success. Performing fractal analysis of tissue samples, it’s possible to make a differential diagnoses between the early stage of tumours and flogosis, or among the different types of Basal Cell Carcinoma, and different grade of Invasive Bladder Carcinoma, well as to investigate the subtle alterations of the nuclear patterns in human breast tumours, or to evaluate other tumours.

How to cite: Alia, L. (2022). The application of the fractal analysis in oncopathology. Medicus, 6(1), 77–84.

https://doi.org/10.58944/xled6943