Mycosis Fungoides. Differencial Diagnosis

by, MD. Daniela NAKUCI, MD. Erisa KOLA, PhD. Leart BERDICA, Prof.Dr. Mehdi ALIMEHMETI

Abstract

Background: Mycosis funguides (MF) is a rare malignant skin neoplasms, and one of the most common primary cutaneous T cell lymphomas. MF have the appearance of many skin lesions, particularly in its early clinical course, creating diagnostic challenges, especially in our country ( growing countries) as it requires tissue biopsy, histological diagnosis with hematoxylin & eosin, immunohistochemistry and molecular diagnostic elements. 71 MEDICUS / NO. 3, 2020 Materials and Methods: Tis is a diferencial diagnosis based on retro and pro spective study, about 6638 articles published in Pubmed for Cutaneous Lymphoma (CL ) with focus MF,33 articles of Primary Cutaneous CD 30+,WHO-EORTC classifcation for CL and recently updated articles about MF. All these evidence of the MF were reviewed and analyzed. Results: In this study was reviewed, the importance of bioptic examination for the diagnosis of MF and other examinations such as immunohistochemistry, and the histopathological fnding of MF were again reviewed and defnied. And it was given a panel of the diferential diagnosis of this pathology that mimics many infammatory pathologies in particular Spongiform Dermatitis, and neoplasmic skin lesions like Sezary Syndrome and Primary Cutaneous CD 30+- T cell Lymphoma, to warn clinicians of the wide spectrum of this difcult disease. Conclusion: Te classifcation of cutaneous lymphomas is multidisciplinary and needs the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. It is important to be suspected of MF when an erythematosus process has long-lasting progression, poor responses to medications for other infammatory pathologies, and most importantly during histopathological examination to detect atypical lymphocytes in the epidermis.