Chronic myeloid leukemia 2018 update on diagnosis, therapy and monitoring

by, A. Cili, A. Perolla, E. Calliku, P. Pulluqi, T. Caja, A. Ivanaj

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1-2 cases per 100 000 adults. CML is characterized by a genetic translocation, t(9;22)(q34;q11.2), this rearrangement is known as the Philadelphia chromosome. The molecular consequence of this translocation is the generation of a BCR-ABL1 fusion oncogene, which in turn translates into a BCR-ABL1 oncoprotein.